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mavorixafor will increase the stage or result of codeine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a strong CYP2D6 inhibitor) is contraindicated with prescription drugs which can be remarkably dependent on CYP2D6 for clearance.Severe Allergic Reactions. Dextromethorphan may well lead to allergic reactions, that m